How Vaccines Might Improve Long Covid

A working hypothesis from an expert immunologist

Photo: Karen Ducey/Getty

To determine which mechanism(s) are responsible for vaccine-mediated improvement in long Covid, we can design a trial in which long haulers are given one of four vaccines.

Another possible way in which vaccines can help long Covid symptoms is through stimulation of innate immune responses, caused by the adjuvant component of the vaccines. Vaccines induce T and B cell responses. This requires two components, antigen (the stuff detected by T and B cell receptors) and adjuvant (the stuff that triggers innate immune responses).

Immunologist working on viral infectious diseases and vaccines. Professor at Yale. Investigator of Howard Hughes Medical Institute. Love teaching and learning.