New Study Says Common Painkillers Could Make People Riskier

Surprising effects on the brain found in widely used over-the-counter drugs

Robert Roy Britt
Elemental
Published in
4 min readSep 22, 2020

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Photo: AsiaVision/Getty Images

Acetaminophen, the pain-killing ingredient in Tylenol, alters a person’s perception of risk, potentially leading to behaviors they would otherwise not consider, preliminary new research suggests. The drug can also lower physical pain caused by emotional distress such as hurt feelings and even lessen our empathy for other people, other research finds.

Ibuprofen, the active ingredient in the painkiller Advil, has also been found to alter emotions, raising overall questions about the broad psychological effects — poorly understood, as of now — of over-the-counter medications consumed by tens of millions of Americans daily, often in higher-than-recommended doses.

People taking acetaminophen in the new study, published in the journal of Social Cognitive and Affective Neuroscience, had fewer qualms about things like bungee jumping or speaking up about an unpopular issue at work. They also took greater risks in games played for prizes.

“Acetaminophen seems to make people feel less negative emotion when they consider risky activities — they just don’t feel as scared.”

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Robert Roy Britt
Elemental

Editor of Wise & Well on Medium + the Writer's Guide at writersguide.substack.com. Author of Make Sleep Your Superpower: amazon.com/dp/B0BJBYFQCB