In a March 2019 study, researchers at Johns Hopkins Medicine reported that they had identified and tested a new compound for depression that may work differently from all other depression drugs on the market.
As part of the study, researchers put mice in a cage with a bigger and more aggressive mouse for 10 minutes a day. The smaller mice were bullied and started to isolate themselves by hanging out in an empty corner of their cage. These “depressed” mice were then given daily doses of a new compound called JHU-083, which succeeded in bringing back the rodents’ sociable personas.
With his retirement approaching, Joe Schiel was experiencing heightened levels of anxiety and stress. His doctor prescribed a generic version of Lexapro, an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRI), to ease a difficult transition. Nearly a month later, he jumped off a hotel’s fourth-floor balcony.
Stewart Dolin started taking paroxetine, a generic version of the SSRI Paxil, following the stress of increased responsibilities at his job. Just six days later, he leaped in front of a moving train.
The deaths of Dolin and Schiel, who were both in their fifties, stunned their families. Dolin…
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Roughly one in eight Americans older than 12 is on antidepressants, and a quarter of the people who take these drugs have done so for more than 10 years. That’s according to some of the most recent mental health data collected by the Centers for Disease Control and Prevention (CDC). Considering that tens of millions of Americans are now taking selective serotonin reuptake inhibitors (SSRIs) and other antidepressants, one would reasonably expect that…