Exact Sciences employees, Scarlett Lee and Xavier Robinson, holding samples. Photography: Lyndon French

Inside the Effort to Test Millions of Stool Samples for Cancer

Colon cancer screening should begin at age 45, new guidelines say. During a pandemic, this at-home poop test has emerged as a key solution.

Ron Winslow
Elemental
Published in
17 min readOct 30, 2020

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As the number of Covid-19 cases began to explode in the U.S. in March and April, Americans retreated to their homes and put routine medical care on the backburner. Not getting Covid-19 — and protecting health care workers against the disease — became the collective goal. Traditional doctor visits plunged, elective procedures were canceled, and any other care deemed nonessential — including cancer screenings — essentially came to a halt. Specifically, the number of colonoscopies, the bedrock of colon cancer screening, fell nationally by 90%.

The disruption at Exact Sciences was almost immediate. The company is the maker of a colonoscopy alternative called the Cologuard test, which screens poop samples for cancer DNA. Exact saw the number of its poop-filled kits arriving for analysis at its Madison, Wisconsin, headquarters plummet by 80%. Like many businesses around the country, Exact froze its spending, imposed pay cuts, and furloughed some employees. The pandemic “has been a real step back in our efforts to prevent cancer and detect it early with colon cancer screening,” says Kevin…

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Ron Winslow
Elemental

Medical and science journalist now living in Mount Washington Valley, NH, after 33+ year-career as a reporter and editor at The Wall Street Journal.