Why Vaccines Are So Difficult to Develop

An inside look at why we are so far from a Covid-19 vaccine

Jesse Smith, MD
Elemental

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Photo: Jeff Pachoud/Getty Images

The first major outbreak of a coronavirus was nearly two decades ago. As that strain raged through Asia, there was an immediate effort to develop treatments and vaccines against the novel pathogen. Impressive measures were put into place to curb the spread of the disease and prevent people from contracting it. Vaccines stood as the crown jewel of this effort: to develop a safe and effective one would have been a monumental accomplishment.

Roughly a decade later, after the dust had settled on the original SARS outbreak in Asia, a new strain of the coronavirus emerged in the Middle East causing a similar spectrum of disease symptoms. This new strain, now known as MERS-Cov, ran a similar course. Again, a renewed enthusiasm for developing vaccines surfaced.

Now, nearly two decades from the original SARS outbreak, we face yet another novel coronavirus outbreak, this time emerging from China. This one has, of course, spread rapidly throughout the globe. This pandemic is reminiscent of the prior two coronavirus outbreaks but dwarfs them in its transmissibility and lethality. Once again, the medical community jumped into action to develop drug treatments and vaccines against the newest strain of coronavirus, now known as SARS-Cov-2…

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Jesse Smith, MD
Elemental

Physician and molecular biologist. I write about topics in science and medicine that relate to everyone.