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The Nuance

Why Does Inflammation Seem to Underlie All Sickness?

It’s a culprit in diseases ranging from arthritis to depression

Illustration: Kieran Blakey

WWriting in 1889, the Swiss pathologist Ernst Ziegler observed that “a brief and precise definition of inflammation is altogether impossible.” Even back then, experts like Ziegler recognized that inflammation manifests in…




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Markham Heid

Markham Heid

I write about health, science, and psychology. My work has appeared in Time magazine, the New York Times, Vice, and elsewhere. I live in Germany.

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